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Volume 53, Issue 4, 2025
Online ISSN: 2560-3310
ISSN: 0350-8773
Volume 53 , Issue 4, (2025)
Published: 30.06.2025.
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Contents
01.12.2014.
Professional paper
ZNAČAJ KOMPJUTERIZOVANE TOMOGRAFIJE U VIZUELIZACIJI PATOLOŠKIH PROCESA MEZENTERIJUMA
CT dijagnostika peritonealnog prostora predstavlja kompleksan deo za skeniranje i teško ga je predstaviti na aksijalnim presecima, jer je normalno zakrivljen u ravni. Prisustvo „zamagljenog“ ili „misty“ mezenterijuma, najčešći je znak prisustva patoloških procesa u peritonealnoj duplji. Normalno subperitonealna mast je niskih izmerenih atenuacija, te svako povećanje atenuacije ovih struktura (od -60 do 0 HU) dijagnostički je značajno. Cilj istraživanja je bio da procenimo ulogu kompjuterizovane tomografije,u eksploraciji i vizuelizaciji patoloških promena mezenterijuma. Studijom preseka obuhvaćeno je 28 osobakod kojih je obavljen CT pregled abdomena i male karlice u okviru Službe za radiološku dijagnostiku KBC „Dr Dragiša Mišović-Dedinje“ u Beogradu. Korišćen je standardni protokol snimanja abdomena, zasnovan na dinamskom ispitivanju protokolom po Rossi-ju. Sva snimanja obavljena su na 16-slajsnom skeneru. Kod 18 od ukupno 28 osoba (64%), videle su se promene na mezenterijumu koje su bile inflamantornog porekla, od toga promene po tipu “misty” mezenterijumauočene su kod 6 osoba sa pankreatitisom (33%), kod 4 osobe sa apendicitisom (22%), kod 7 osoba sa divertikulitisom (39%), a kod jedne panikulitis sa pseudokapsulom u vidu masnog prstena (6%).U 2 osobe (7%), uočljen je“misty” mezenterijum kao posledica tromboze gornje mezenterične vene,dok je kod 2osobe (7%),mezenterijum bio izmenjen kao posledica hemoragične ishemije tankog creva. Jedna osoba (4%), je imala patološki izmenjeni mezenterijum zbog primarnog tumora tankog creva (karcinoid), a kod 5 osoba (18%) bile su prisutne adhezije kao posledica sekvela nakon hirurških intervencija i zračne terapije.Senzitivnost CT dijagnostike za dobijanje pozitivnih rezultata kod osoba koje imaju inflamantorno izmenjeni mezenterijum iznosila je 90%,specifičnost metode iznosila je 87.5%.. pozitivna prediktivna vrednost 94.7%, a negativna prediktivna vrednost 77.8%, uz tačnost metode 89.3%. Na osnovu visokih vrednosti senzitivnosti i specifičnosti testiranih pregleda u ovoj studiji preseka, CT dijagnostika peritonealnih prostora ima obavezno mesto u dijagnostičkom algoritmu. Zahvaljujući multidetektorskim skenerima proširene su mogućnosti eksploracije peritonealnih prostora, ali uprkos velikom doprinosu softverskih rešenja, minucioznost pri pregledu, kao i visok nivo znanja bitne su pretpostavke u radu, pa pregled ovih prostora uvek predstavlja dijagnostički izazov.
M. Gašić, I. Bogosavljević, M. Šaranović, S. Stajić
01.12.2015.
Professional paper
Significance of echotomography in the diagnostic algorithm for acute pyelonephritis and glomerulonephritis
Introduction: In adults the diagnosis of acute pyelonephritis and glomerulonephritis is primarily based on clinical and laboratory-biochemical testing. In patients where the clinical picture atypical, even if a person does not respond to therapy resorts to radiographic examination. Echotomographic examination is unavoidable in the diagnostic algorithm. Objective: The aim of this study was to establish the individual echotomographic parameters, as well as to determine their diagnostic power in patients with acute infections (pyelonephritis and glomerulonephritis), and comparing them with the appropriate reference tests. Materials and methods: We performed a cross sectional study in the period from October 2014. until May 2015. It included 50 patients with acute inflammation of the kidney which was made echotomographic examination of the abdomen and pelvis, within the Department of Radiological Diagnostics KBC "Dragisa Mišović-Dedinje" in Belgrade. The echotomographic examination of the kidneys included testing of numerous parameters that could indicate the existence of an acute inflammation of the kidney. For the gold standard, we take the findings obtained by CT (computed tomography) imaging of the abdomen and pelvis, as well as histopathological findings obtained by fine needle bio-psy. Results: At 50 patients with acute inflammation of the upper urinary tract, 41 patients (82%) had acute pyelonephritis, and 9 (18%) had acute glomerulonephritis. In 70% of patients with acute pyelonephritis (29 people) were present enlargement of the kidney where the test sensitivity was 79.3% and specificity of 91.7%. The accuracy of the method was 82.9% when the monitored parameters: loss of central echo complex and cortico-medullary differentiation. The sensitivity of the test in which the observed thickening of the pelvic and ureteric wall was 65% and specificity of 90%. The analysis of the presence of calculus in renal parenchyma leads to the values of sensitivity test of 54.8% and specificity of 80%. Hypoechoic focus in the renal parenchyma, enlargement of the kidneys and loss corticomedullar limits are parameters who with great sensitivity and specificity suggest acute glomerulonephritis. Conclusion: On the basis of high values of sensitivity and specificity of the test survey estimates that ultrasound has a required place in the following diagnostics algorithm. The use of echotomography that offer the possibility of high resolutive views, as well as the wide availability and good reproducibility of the method, the low cost of inspection, in favor of the first exploration ultrasound examination. Multidetector CT scan and fine needle biopsy remains the method of choice for the definitive diagnosis.
Ivan Bogosavljević, M. Gašić, T. Filipović, P. Mandić, N. Đukić-Macut, M. Šaranović, S. Stajić
01.08.2015.
Professional paper
Comparative analysis of numerical density of ganglion cells with certain content of lipofuscin pigment in the parts of symphatetic trunk during the aging
The neurons of the sympathetic trunk as well as the other nerve cells undergo of many changes during life. The most striking of these morphological changes, during normal aging, is the accumulation of lipofuscin-filled vacuoles or neuromelanin. Considering that the pigment is a non-biodegradable and can not be removed by exocytosis, the process of its accumulation in cells is unavoidable. The role of lipofuscin and its impact on cell function is not quite clear. Some authors consider that pigment does not damage the function of the cell, unless it contains lipofuscin in large quantities, and then it mechanically prevents its function so that could lead to cell death. Since we found a very little data in the literature about using morphometric methods in accumulation of pigment in ganglion cells or quantified observed changes, we set that the aim of this study is to confirm the presence of pigment in ganglionar cells of the symphatetic trunk, when it occurs in grater extent, as well as dinamics of its accumulation (quantification of ganglionar cells without pigment, those with partial presence of pigment, and those that were complitely filled with pigment) by using numerical density. For morphometric analysis we used test system M42. To determine the numerical density of ganglionar cells we used a method for thick cuts by Floderus. We found that interneuronal accumulation of lipofuscin is directly correlated with the aging process.
T. Filipovic, P. Mandic, M. Filipovic, N. Djukic, S. Matejic, M. Saranovic
01.12.2013.
Professional paper
DNA identification of war and mass catastrophies victims
After the armed conflicts throughout the nineties of the twentieth century occurred in former Yugoslavia, identification of war victims is a challenging task. This paper gives a detailed description of exhumed remains identification process. One of the study objectives has been a comparison between DNA results and traditional forensic identification methods. This paper deals with the identification of human remains that were exhumed in Kosovo and Metohia in the period 2001-2012, belonging to Serbs and other non-Albanian ethnic communities (Montenegrins, Bosniaks, Roma, Gorani, and others), as well as much lower number of Albanians who were also killed during the war and post-war period.The experience of this process and the experience of other countries show that there is a need to organize appropriate services for identification of human remains in Serbia, capable to react effectively in case of mass disaster.
S. Matejic, M. Miletic, M. Milosevic, V. Jaksic, T. Filipovic, M. Saranovic, N. Deletic
01.01.2007.
Original scientific paper
MACROSCOPIC VARIABILITY OF STUCTURES OF LOBULUS PARIETALIS AND PRECUNEUS
Traumas of CNS are more often and more complex than ever, also the influence of the factors of environment are more destructing, so all of them require detail knowledge of the morphology and functions of the nervous system. It is necessary for the faster and more accurate diagnosis in clinical medicine, and also it is necessary in preventing diseases of CNS. Modern neuroimaging procedures such as CT, MRI, PET, require precise knowledge of both morphologic variations of human brain , and the relation between morphology and function. In this kind of research the best solution is combination of descriptive and quantitative methods
N. Đukić-Macut, Z. Vitošević, T. Filipović, P. Mandić, M: Milisavljević, M. Šaranović
01.12.2007.
Original scientific paper
МОRPHOLOGICAL AND MORPHOMETRIC ANALYSIS OF ACCUMULATION THE LIPOFUSCIN PIGMENTIN GANGLIACELLS IN THE CERVICAL PARTOFSYMPATHETIC TRUNK IN THE PROCESS OFOLD AGE
Old age can be defined as a variety of changes in structure and function which begin at the stage of reproductive maturity, and that changes are manifested as a lesser ability of adaptation and lesser way of defending from the influence of outside and inside factors. Neurons of sympathetic trunk, as well as the other neuron cells, are changeable during the life. Neurobiological, old age begins at the time of birth, because the number of neurons is not increasing, it's only getting lower, which means that neurons are post mitotic cells. The process of old age is increased with some degenerative changes at some diseases and its hard to know what belongs to, so called, physiologic way of getting old and what is pathologic. Concentration of lipofuscin in cells (pigment of old age), is the parameter for physiologic old age of a person. Concentration is changeable, and it depends from the tissue or the organ, concentration is controlled by the internal regulatory factors and the factors of environment as the way of nutrition, physical activity, stress and hygienic factors.
T. Filipović, N. Stefanović, Z. Vitošević, M. Milisavljević, N. Đukić, P. Mandić, S. Matejić, M. Šaranović