Probiotics help to provde optimum balance in the intestines probiotics species competitive blocks toxics substances and growth of unwanted species in their struggle for space and food. Lactogyn is the first oral probiotics wich protects vaginal flora. The most researced probiotic is the Lactobacillus rhamnosssus. The goal of this study is to exam influence of probiotics to cytological smear test including: reliability for easier detection of atypical cells; false positive and false negative test; faster cytodiagnostic; incidence of invasive diagnostic procedures and incidence of intraepithelial and invasive changes of the lower genital tract. This study involved two groups of patient: the first one included 50 patients who has been taken specific probiotic therapy after taking cytological cervical smear test. The second one included 50 patients who has taken specific probiotic therapy before taking cytological cervical smear test. In the second group we discovered: statistically lover number od invasive diagnostic and therapeutic methods and statistically higher number of patients without invasive methods. It was statistical higher incidence of cytological smears with inflammations and ASCUS (atypical squamous cells undetermined significance) in the second group of patients. Lactogyn treatment with other medicament therapy provides: faster and better cytological diagnostic, decreases the number of cytological tests and invasive diagnostics methods per women, decreases the number of false positive and false negative tests and the percent of unsatisfactory tests and borderline satisfactory tests

We tested the performance of telecolposcopy in the diagnosis of various squamous intraepithelial lesions. There were three groups of physicians: Group 1 consisted of 15 gynaecologists who were not trained in colposcopy; Group 2 consisted of six experienced colposcopists (specialists); Group 3 was a supervising team constisting of three experts (colposcopists with more than 15 years of colposcopy experience). The first group took colpophotographs during gynaecological examinations and used a Web browser to compare them with examples from a database of colposcopy findings. Group 2 made their own diagnoses independently. Then the supervising team examined the findings from all 250 patients and made diagnoses that could be considered the ''gold standard''. The findings were identical for Groups 1 and 2 in 219 cases, i.e. an inter- observer agreement of 88%; Cohen's kappa was 0.81. The findings were identical for Groups 1 and 3 in 208 cases, i.e. an inter- observer agreement of 83%; Cohen's kappa was 0.74. The findings were identical for Groups 2 and 3 in 239 cases, i.e. an inter- observer agreement of 96%; Cohen's kappa was 0.93. There was high inter- observer agreement between all participants. However, there were also significant differences in some cases. In the cases of suspected invasive carcinoma, 2 the results showed a significant difference (x =4.8, p < 0,005) because gynaecologists from Group 1 were not sure of their diagnosis and they wanted to obtain a second opinion by referring the decision to a higher level.