Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine has been commonly implicated in SJS. We report a case of SJS-TEN overlap syndrome developing in patient who was prescribed carbamazeine after epileptic attack during radiotherapy for the purpose of treatment Glioblastoma multiforme, patients underlying disease, whose symptomatology deteriorated patients condition.