Acute organophosphate (ÎÐ) poisoning is an important cause of morbidity and mortality in children especially in the developing countries. Published studies work have been reported on acute childhood poisoning has focused mainly on the epidemiological trends, with little information about alteration in electrolitic and acid-base equilibrium and other disturbance and on the management of the poisoned children. Hypovolaemia, electrolyte derangements and acidosis are major predisposing factors for development of complications. Metabolic acidosis is one of the major causes of death in patients poisoned with OPC acutely. We suggest that children's with acute OPC poisoning should be screened for electrolyte and metabolic acidosis with blood gas analysis.

It is argued that the easy availability and widespread use of highly hazardous organophosphate compounds (OPC) is the most important reason for this high number of poisoning. In this study socio pediatrics aspects of children¢s acute intoxications OPC were investigated.Data collected included age, gender, time, rout of åxposure, place of accident, first aid before admission. Àll were do to accidental event attempted suicide cases. Acute OP poisoning is a the important cause of morbidity and mortality and represent serious condition that needs rapid diagnosis and tretman because. Therapy should be started as early as possible beginning from primary and secondary level so undesirable consequences can be avoided.

Despite of Aspirin use in acute virus infection and reduce of incidence in many parts of the world, the Reye's syndrome is also actual in our country. Reye's syndrome was described for the first time in 1963. It's a non-inflammatory encephalopathy and lipid infiltration of liver and other organs. Etiology is unknown. Some viruses, some chemical compounds,
Aspirin and genetically abnormal answer have the role. The damage of mitochondria appears. Organism is in hard catabolism. The biochemical parameters in serum and liquor were followed at 26 children cured in treated in Pediatrics Clinic in Priština in the period from 1991-1998. The extreme hypoglycemia (<2.2 mmol/L) was in 46,1%, medium hypoglycemia
(2,3-3-,3 mmol/L) in 7,7%. Three times high transaminases appeared in 46% of children. The level of chaemostasis was reduced in 11,5% of children. Half of the total number children had the higher values of urea and creatinine. Hyperproteinorachia in liquor was 27% and hypoglycorachia was 19,3%. Metabolic acidosis was present in 61,5%. Half of the children had convulsions and pneumonia. Enterocolitis, acute renal insufficiency, anemy and urinary infection were also present.