The most important adipocytokines affecting the formation and the regression of atheromas plaque in the coronary blood vessels are adiponectin and resistin. The essence of this test is to determine the correlation of the leading biochemical parameters of atherosclerosis, adiponectin and resistin and determine their interdependence with other biochemical parameters in patients with diabetes mellitus and coronary heart disease. Our study group consisted of 140 patients and 40 control group (healthy), 50 with diabetes mellitus and 50 with coronary heart disease (myocardial infarction and angina pectoris). We find that the average value of adiponectin in the group with type 2 diabetes mellitus were significantly lower than in the control group (4.38 to 6.74, p = 0.001, p <0.05). In the same study group average value of resistin was significantly higher than in the control group (15.8 to 7.88, p <0.001). The average value of adiponectin and resistin in patients with myocardial infarction and angina pectoris are no different from the value obtained in diabetes mellitus (4.94 to 4.38 and p = 0.397, p> 0.05). In the same study group average value of resistin was significantly higher than in the control group (15.73 to 7.88, p = 0.001, p <0.01) and not different than in the group with diabetes mellitus. Values Pearsonovg correlation coefficient shows that the biggest falls inversely proportional dependence of adiponectin with a simultaneous increase in resistin is expressed in patients with myocardial infarction, which is expressed very good correlation coefficient (-0.36). In all the groups, shows that there is a negative correlation between resistin and adiponectin, with increasing values of resistin values of adiponectin are reduced.

Tests have shown that adipose tissue is very important in the production of chemical substances that have a major impact on atherosclerosis. The basic fat cells adiposity is very active in bio secretion hormones and other substances. Adiposities secrete chemical substances such as leptin, resistin, adiponectin, and others who participate in metabolic processes. One of the most important adipocytokine affecting the formation and the regression of atheromas plaque in the coronary blood vessels are adiponectin and resistin. So our aim was to determine the value of the concentration of adiponectin and resistin on patient with myocardial heart attack and determine their correlation with the control group of healthy subjects. In this study were included 68 subjects, 40 with myocardial heart attacks and 28 control groups of normal healthy. In the group with myocardial 78.6% of respondents were male and 21.4% female. Tests have shown that the concentration of adiponectin in the group with myocardial heart attack was significantly lower than the control group (4.94 to 6.74, p=0.043, p<0.05. In the same study group average value of resistin was significantly higher than in the control group (15.73 to 7.88, p=0.001, p<0.01) (Student's t-test, p = 0.581, p> 0.05). All this indicates that in patients with myocardial heart attack there is a decline in the concentration of adiponectin, which has cardio protective effect. The increase in resistin in myocardial heart attack in directly related to the appearance of athermanous plaques in the coronary blood vessels and has a bad prognostic significance.

Main point of prevention of tuberculosis is the existence of basic knowledge about risc factors (smoking habit, alchohol abuse) which contribute to apperance of tuberculosis and influence to therapy. In order to assess the influence of potential risc factors a crossanalysis was made for the years 2002-2004, 2007-2009 and 2012-2014 . During the period of 12 years, 230 cases of TB were included in the study. The mean age of all subjects was 45.81±16.98. There were (61.7–73.2%) males and this observation is supported by reENGLISH 2014; 43 (3) 23-29 29 ORIGINALNI RADOVI ports that males had signitificantly higher risc for more severe lung destruction (69.2-84.6%), as evidenced by bilateral lung cavitation (86.1-100%) than females. In total 45.6–76.7% were smear-positive. Alcohol use disorders increased (11.8–29.4%; p=0.02) as a smoking habit (44.1–47.1%). In cases with severe lung destruction as a lung cavitation incrised cigarette smoking (46.6–60.0%) and alcoholism (19.4–50.0%; p=0.007). Linear regression analysis confirmed a statistically significant correlation between severe form of TB and smoking habit (>20 cigarettes per day, p=0.04) and alcohol use disorders (p=0.004). Successful control in reducing smoking, alcohol use disorders and, could favorably impact the TB morbidity rate.

Osteoartritis kolenih zglobova je degenerativno oboljenje čije su glavne karakteristike oštećenje i gubitak zglobne hrskavice, zgušnjavanje kosti neposredno ispod hrskavice (subhondralna kost) i hipertrofija kosti na rubovima zgloba. Klinički, OA kolenih zglobova se, u zavisnosti od faze bolesti, ispoljava bolovima u degenerativno izmenjenom zglobu, ukočenošću, ograničenjem opsega pokreta, krepitacijama, izlivom u zglob, deformacijama i različitim stepenom upale. U radu je obrađeno 100 ispitanika i prezentovani su rezultati kliničkih manifestacija oboljenja, koji uključuju anamnestičke i objektivne parametre, sociodemografski status, radiološki nalaz i prisustvo komorbidnih stanja.

Prediktori pobolјšanja kvaliteta života nakon hirurške revskularizacije miokarda su još uvek nepotpuno poznati. Cilj rada je bio da ispita prediktore poboljšanja kvaliteta života šest meseci nakon hirurške revaskularizacije miokarda. Ispitivali smo 208 uzastopnih pacijenata koji su podvrgnuti hirurškoj revaskularizaciji miokarda. Za ispitivanje kvaliteta života korišćen je upitnik Nottingham Health Profile Questionnaire prvi deo. Upitnik se sastoji od 38 pitanja koji su podeljeni u 6 odeljaka: fizička pokretljivost, socijalna izolacija, emocionalne reakcije, energija, bol i san. Upitnik je podeljen svim pacijentima pre i šest meseci nakon operacije. Prosečna starost ispitivanih pacijenata je bila 58,8 ± 8,2 godine, 82% su bili muškarci. Poređenje pre i postoperativnih skorova je pokazalo da se poboljšanje nalazi kod 53,76% bolesnika, pogoršanje kod 12,46%, normalan KŽ pre i posle operacije kod 26,70%, dok je KŽ nakon operacije bez promene kod 7,08% bolesnika. Nezavisni prediktori poboljšanja kod pacijenata nakon operacije su bili: odsustvo prethodnog infarkta miokarda u odeljku fizička pokretljivost (p=0,03; OR=0,59; CI 0,40-0,92), viša CCS klasa angine u odeljcima fizička pokretljivost (p=0,006; OR=2,34; CI 1,46-3,32), energija (p=0,02; OR=1,70; CI 1,29-2,64) i bol (p<0,001; OR=4,64; CI 2,27-7,31), muški pol u odeljku bol (p=0,03; OR=0,45; CI 0,26-0,62) i mlađe starosno doba u odeljku bol (p=0,01; OR=0,69; CI 0,41-0,85). Prediktori poboljšanja kvaliteta života šest meseci nakon hirurške revaskularizacije miokarda su viša CCS klasa angine, odsustvo prethodnog infarkta miokarda, muški pol i mlađe starosno doba.

Dijabetes melitus tip 2 je jedno od vodećíh hroničnih oboljenja u svetu pa i u našoj zemlji, koje predstavlja
značajan faktor rizika u nastanku kardiovaskularnog morbiditeta i mortaliteta. Cilj ovog istraživanja je ispitivanje koji
faktori rizika doprinose nastanku koronarne bolesti kod gojaznih pacijenata sa dijabetes melitusom tip 2. U studiju je
uključeno 82 gojazna pacijenta, od toga 52 sa dijabetes melitusom i 30 bez dijabetes melitusa, sa angiografski dokazanom koronarnom bolešću. Kod svih je sprovedeno kliničko ispitivanje, laboratorijske analize i ehokardiografski pregled. Na osnovu rezultata ispitivanja utvrdili smo da je distribucija faktora rizika kao što su arterijska hipertenzija,
porodično opterećenje koronarnom bolešću, pušenje, konzumacija alkohola bila istovetna u gojaznih pacijenata sa i
bez dijabetes melitusa. Ehokardiografki je nađena statistički značajno veća leva komora, niža ejekciona frakcija, veća
leva pretkomora i značajna mitralna regurgitacija u grupi sa dijabetesom. U grupi sa dijabetesom je takođe češće,
statistički značajno, bila prisutna višesudovna koronarna bolest. Uprkos malom uzorku može se zaključiti da je prisustvo dijabetes melitusa kod gojaznih pacijenata presudno u nastanku težih oblika koronarne bolesti. Težina se ispoljila kroz značajnije strukturne i funkcionalne promene leve komore i broj obolelih koronarnih arterija.  

Within published data, arthropathies in diabetics, alcoholics, trauma, tabes dorsalis, syringomyelia, and scleroderma are judiciously called neuropathic arthropathies (Vargazon). Main common characteristics of these arthropathies are the following: they involve one or more joints; there is edema, deformity, ulcerations, increased pigmentation and myositis ossificans (Reinhardt, Clouse, Thornhill, et al.). The most common findings in diabetes mellitus are neuroendocrine dystrophies of musculoskeletal system. Diabetic osteoarthropathy is common name that refers to rheumatic diseases that are frequently encountered in diabetics. These diseases include: Charcot joint, hyperostotic spondylosis (Forestier's disease), humeroscapular periarthropathy, Dupuytren's contracture, joint contracture with skin thickening in juvenile diabetes mellitus, etc.