Leukoaraiosis is a change in brain white matter with characteristic manifestation in MR and CT head scans. Common leukoaraiosis risk factors include aging and arterial hypertension. A quarter of symptomatic ischemic infarcts belongs to small blood vessel disease group and could be presented as lacunar infarcts. These two crucial pathophysiological mechanisms are in the root of cognitive dysfunction related to small blood vessel disease. 60 lacunar infarct patients were examined and parameters for groups with and without leukoaraiosis were determined. It was found that leukoaraiosis incidence was highest in the group of women older than 70. Neurological assessment was scored on NIH-NINDS scale, functional status was scored with Barthelo index, and cognitive status was determined using Mini Mental State Examination (MMSE) and Alzheimer Disease Assessment Scale Late (ADAS-L). Correlation analysis of these parameters on significance level of *p<0.05, **p<0.01, suggests decrease in neurological status and cognitive performance.

Epidemiological characteristics of acute stroke certify the great importance of such disease, which takes the measures of a mass incontagious illness, because it represents one of leading causes of death and invalidity in the world. Contemporary knowledge about the complexity of cerebral infarct has been significantly increased thanks to new imaging methods, which allows correction of clinicaly stated diagnose. The aim of our research was to determine clinical manifestation signs of supratentorial infarcts and their presence compared to anatomic localisations of lesions. 60 patients were clinicaly tested, and a computerised tomografy of brain followed, which disclosed anatomic localisation of lesions. Results have shown that the maniestation of supratentorial infarct in the AMC zone has the most neurological signs, from conscious state disorders, graver pyramid deficit, speaking disorder to hemihypesthesia and hemianopsys. Lighter neurological deficit is found in infarcts which affect AAC and APC zones, which brings to a conclusion that knowing the clinical state and without applying neuroradiological methods can imply to localisation of supratentorial infarcts.

Clinical praxis shows that patients with panic disorder have experienced different stressful life events which could be linked with the onset, development, and maintenance of the disorder. The aim of the study was to analyze the life events occurring one year before the onset of the panic attacks. The research has been conducted on the Psychiatry and Neurology Clinic, Clinical-Hospital Center Pristina, Gracanica. The sample consists of 84 patients with panic disorder. The data were obtained using the Questionary NIMH PQ consisting of 11 stressful life situations and a possibility for the participants to add a life event that was not included in the questionary. The standard descriptive and analytic statistic methods have been applied. The results revealed that a majority of patients (88%) have experienced some stressful life event in the period of one year before the first panic attack. The most common life event was change of life space. The second frequency has loss of job, following with death of a family member, disease, traffic accident, and continuing education moving to a different town. It can be concluded that stressful life events can be significant factors for the onset, development and maintenance of panic disorder. 

Hyperprolactinemia is the most common hypothalamic-pituitary axial disorder which is found in clinical practice. Increased level of prolactin, regardless of the cause, results in disorder of gonadal function and infertility, while normalization of the level of prolactin is associated with establishment of normal gonadal function and fertility. Establishment of the correct diagnosis is a great significance, because it is possible to normalize the level of prolactin and establish normal function of ovaries in more than 90% cases with specific therapy. The objective of the work is to study concentration of prolactin in each phase of menstrual cycle, its impact (influence) on FSH, LH and E2, as well as the influence of hyperprolactinemia on the rhythm of menstrual cycle. The study has encompassed 150 of women in reproductive period, from 18-40 years of age. The control group includes 50 of women, and there are 100 of women with menstrual cycle disorders (oligomenorrhea, polymenorrhea and secondary amenorrhea) which causes hyperprolactinemia. The turnout of hyperprolactinemia in causes the disorders of menstrual cycle (oligomenorrhea, polymenorrhea, amenorrhea) is 83%, on the basis of the results, wich demonstrates a serious problem and justifies a scientific study.