Aim of this work was to ascertain kind and frequency of skin sensibility to inhalation allergens and determine importance of skin allergic "prick" test. Investigation was accomplished on 141 patients by skin allergic test in vivo with standard "prick" technique. The results of work have showed that allergy is unquestionably present in the rhinosinusal diseases, as well as certain relationship between these diseases and allergic skin "prick" test, but this relationship was insufficient to determine skin allergic "prick" test as enough sensitive and specific diagnostic method for diagnose allergic rhinosinusal diseases. "Positive" allergic skin "prick" test demonstrate patient's hypersensitive reponse on inhalation allergens and existence of allergy, but not the direct connection between this hypersensitive reaction and rhinosinusal diseases. "Negative" allergic skin "prick" test not exclude existence of allergy, and for that, patients which have suspect allergy at the aim of further investigation must be apply other more sensitive and specific diagnostic method.