Prediktori pobolјšanja kvaliteta života nakon hirurške revskularizacije miokarda su još uvek nepotpuno poznati. Cilj rada je bio da ispita prediktore poboljšanja kvaliteta života šest meseci nakon hirurške revaskularizacije miokarda. Ispitivali smo 208 uzastopnih pacijenata koji su podvrgnuti hirurškoj revaskularizaciji miokarda. Za ispitivanje kvaliteta života korišćen je upitnik Nottingham Health Profile Questionnaire prvi deo. Upitnik se sastoji od 38 pitanja koji su podeljeni u 6 odeljaka: fizička pokretljivost, socijalna izolacija, emocionalne reakcije, energija, bol i san. Upitnik je podeljen svim pacijentima pre i šest meseci nakon operacije. Prosečna starost ispitivanih pacijenata je bila 58,8 ± 8,2 godine, 82% su bili muškarci. Poređenje pre i postoperativnih skorova je pokazalo da se poboljšanje nalazi kod 53,76% bolesnika, pogoršanje kod 12,46%, normalan KŽ pre i posle operacije kod 26,70%, dok je KŽ nakon operacije bez promene kod 7,08% bolesnika. Nezavisni prediktori poboljšanja kod pacijenata nakon operacije su bili: odsustvo prethodnog infarkta miokarda u odeljku fizička pokretljivost (p=0,03; OR=0,59; CI 0,40-0,92), viša CCS klasa angine u odeljcima fizička pokretljivost (p=0,006; OR=2,34; CI 1,46-3,32), energija (p=0,02; OR=1,70; CI 1,29-2,64) i bol (p<0,001; OR=4,64; CI 2,27-7,31), muški pol u odeljku bol (p=0,03; OR=0,45; CI 0,26-0,62) i mlađe starosno doba u odeljku bol (p=0,01; OR=0,69; CI 0,41-0,85). Prediktori poboljšanja kvaliteta života šest meseci nakon hirurške revaskularizacije miokarda su viša CCS klasa angine, odsustvo prethodnog infarkta miokarda, muški pol i mlađe starosno doba.

Prostatic intraepithelial neoplasia (PIN) is putative premalignant lesions of the prostate. This lesion has role as precuror of prostatic carcinoma (PC), predictive role for PC and high coexistens with PC. Existed two grade of PIN: low grade PIN (LGPIN) and high grade PIN (HGPIN). PC is most important malignacy in man and has high mortality in male. The aim of research was to invastigated morphological comparative patterns of HGPIN and PC. We analyzed biopsy material of 299 cases (cs). We used histopathological metods of investigation. We found HGPIN in 42 cs (14.0%) with mean age 66.3 y and PC in 35 cs (11.7%) with mean age 70.7 y. HGPIN was most frequently in the seventh decade of life (54.8%), and PC in the eight decade (45.4%). Four common pattern of HGPIN were identified: tufting (78.6%), micropapillary (72.8%), cribriform (16.6%) and flat (9.5%). In 21 from 35 cs (60%) with PC was coexistent HGPIN. HGPIN we found in the periferial part in the 22 cs. (52.4%) and in the periurthral part of the prostate in the 12 Cs. (28.6%). HGPIN were multicentric in the 22 cs. (52.4%), in the 15 cs. (68.2%) in the periferial part, and in the 7 cs (31.8%) in the periurethral part of the prostate. PC in the 22 cs (62.9%) was localized in the periferial, and in the 7 cs in the periuretral portion of the prostate. PC was multicentric in 28.6%. Important histological patterns for distinction HGPIN i PC are: disruption of basal cell layer, perineural invasion, mitotic figures, multiple nucleoli, collagenous micronodules, infiltrative growth. HGPIN and PC we found in sufficient percentage. Both lesion were most frequently multicentric, periferial localisation and coexistent. Because of that these lesions needed serious clinical and histological investigations for patients.