Sindrom opstrukcijske apneje u spavanju (SOAS) je poremećaj disanja u kome se javlja delimična ili potpuna opstrukcija gornjih disajnih puteva, što ometa normalnu ventilaciju pluća i tako remeti normalan obrazac spavanja. Klinički se ispoljava habitualnim hrkanjem, često udruženim sa zastojem u disanju, i znacima napornog disanja tokom spavanja, kao i različitim neurobihejvioralnim problemima koji se javljaju tokom dana. Neprepoznat i nelečen SOAS može dovesti do trajnih, pa i životno opasnih posledica. Svaki pacijent sa smetnjama disanja vezanim za spavanje trebalo bi da bude podvrgnut polisomnografskom ispitivanju tokom noći.

Apert syndrome is named for the French physician, Eugen Apert who was, in 1906. described anomalous shape of the skull with coronary suture synostosis and hypoplasia sphenoethmoidmaxillary part of the face and fingers syndactyly of hands and feet. Apert syndrome accounts for about 4,5% of all craniosynostosis. With the prevalence of 1:160 000-200 000, inherited in an autosomal dominant, and in 25% of cases are fresh mutations in the gene. This syndrome has no predilection by gender and race, varies in severity form in witch it is manifested. Anomality of internal organs are very rare, but half of the patients with this syndrome have mental retardation. Apert syndrome has no cure, but surgery can help to correct some of the problems.