The purpose of this study was to evaluate the effect of aspirin and ticlopidine, administered alone and in combination, on liver function parameters. The experiment was conducted on white laboratory rats, type Wistar. Thirty-two rats were divided in four groups and they recived one of the following treatments for 4 days: group I, control, saline (1 ml/kg, i.p.); group II, aspirin (50 mg/kg/day i.p.); group III, ticlopidine (125 mg/kg/day i.p.) and group IV, aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day i.p.). After the treatment the animals were anaesthetised with ether and blood for further analyses was taken by cardiopunction. The total cholesterol serum level was significantly increased only in ticlopidine group in comparison to control (p<0.01).Also, the serum activity of alkaline phosphatase and total bilirubin concentration were significantly elevated only in ticlopidine treated group (p<0.001). Serum AST and ALT activities were not significantly elevated in all treating groups. On basis of the obtained results it can be noticed that the values of liver function parameters are greater in group treated with ticlopidine than in group treated with ticlopidine and aspirin combination.