Ankylosing spondylitis is a chronic rheumatoid inflammation with characteristic synovitis of sacroiliac joints and vertebrae of spinal column and fewer coxofemoral and glenohumeral and periferal joints. The disease is of an unknown etiology and shows strong correlation with histocompatibile antigene HLA-B27 wich is found in 90% AS diseased patients. Acute anterior uveitis is the most frequent extra-articular manifestation, it can precede spondylitis and is found in at least 20% AS diseased patients. Acute anterior uveitis is mostly bilateral, with recidives and in inadequate treatments results in complicate cataract and secondary glaucoma. Out of 41 patients with ankylosing spondylitis 36 (87.8%) is of male , and 5 (12.1%) female sex (ratio 9:1). The youngest patient was 25 and the oldest 69 years of age, average age of the diseased was 38.45. Acute anterior uvetis is found in 11, that is 26.8% diseased patients. The length of uveitis is approximately 28+/- 10 days. In 7 patients (63.64%) AAU is found in both eyes. Out of 11 patients with with AAU, 3 patients (27.27%) had more than first attack,7 (63.64%) had 1-5 recidives, and only 1 patient had more than 5 recidives. The most frequent type of exudation is serofibrose (77.78%), then follows fibropurulent-hypopyon (16.67%) and serose (5.55%). Out of 18 eyes, in 14 (77.78%) back synechies were formed. However, these synechies are in most cases broken by the use adequate therapy.