Patients with epilepsy more often than healthy individual have cognitive disorders, what may be the result of different factors, among which significant place occupy the treatment with antiepileptic drugs. Topiramate is the new antiepileptic drug, which is related with high efficiency in the reduction seazures, and also whit high prevalention of cognitive adverse events. Purpose of our study is to clarify the role of depression in developing cognitive adverse events during therapy with topiramate in patients with refractory epilepsy. In the prospective stady we followed 40 adult patients with refractory epilepsy, which treatement took place on the Institute of neurology Clinical center of Serbia. All patients are neuropsychological tested twice. First time before the start of therapy with topiramate on basic antiepileptic therapy, and next time two months after the achieving of stable dose of 200mg/day. We used neuropsychological tests for evaluation attention, concentration, visual and verbal memory, speech, executive functions, divergent opinion and visual construction abilities. For estimate degree of depression we used Hamilton's scale of depression. Patients with the depressive manifestation had lower scores on cognitive tests in comparition to patients without the depression, before and after introductions topiramate. More the score of depression was larger, the scores of neuropsychological tests have been worse. Depression has bad influence on the cognitive functioning and her presence in the patients with epilepsy increases the risk from development of cognitive adverse events of topiramate.

One of aims of health surveys is comparison helth status of residents on different territories. Comparative analysis оf health surveys in five countries: (England, USA, Ireland, Canada and Hungary) and establish opportunities for comparison health status of residents in different country. Will be doing comparative analysis of results from health surveys in five quoted country. First of all, will be doing comparison of methods and derived results. Specially, will be notice on determinants of health which are applied in surveys. Methodology which was used is, mainly, similar in all country. Its health state like a best describes residents of USA. There are most smokers among Hungarians (30,5%) and least of all among Americans (17%). There are most obeses among residents of England (23,1%) and least of all among Canadians (15%). Most Americans and Hungarians (85%) visited general practitioners in recent year. Questions about limited mobility, depression, mental health, cardiovascular diseases, diabetes, blood pressure, fisical activity, mammography, prescribe medicine, estimation quality of health care service and satisfaction with health care service there isn't in most of surveys. We can conclude that the methodology, which was used in surveys, is mainly similar. There are, obviously, variances in wording questions, respecting in determinants of health wich are exploratives in questionnaires. In order to escape these variances, one of the solution would have been using standardized questionnaires, which will be using in future surveys in all country.

Inhibins are glycoprotein hormones of which there are two molecular forms, inhibin A and inhibin B. Classically, inhibin is known to have a negative feedback effect on pituitary follicle-stimulating hormone secretion. The fetoplacental unit produced inhibin throughout pregnancy. Inhibin Ais the predominant molecular form of inhibin in maternal circulation from 4 week of gestation. Although the precise biological function of inhibin Ain pregnancy is unclear, it is evident from recent studies that inhibin A could be a better marker of placental function than human chorionic gonadotropin because of its shorter half-life. The possible clinical application for the measurement of inhibin Ain early pregnancy could be in predicting miscarriage , Down's syndrome, preeclampsia and fetal growth restriction in the first and/or second trimester before the onset of yhe clinical symptoms. Inaddition, several evidences underline the potential role and the clinical usefulness of their measurements in the diagnosis, prevention,prognosis and follow-up of different gestational pathologies such as:threatened abortion, placental tumors, hypertensive disorders of pregnancy,intrautherine growth restriction,fetal hypoxia.The measurement of inhibin Aand activin Ainto the biological fluids of pregnancy will offer in the future further possibilities in early diagnosis,prediction and monitoring pregnancy diseases.

Search for objective indicators of health state of the population is essential public health issue. First serious attempt of health evaluation of the population were observed in the end of 18. and beginning of the 19. century. In this period of time, description of health population was mostly based on indicators which were based on data of numbers of death. Later, because of significant decrease of infectious disease and improvement of life and work conditions comes to an extension of average life span. Also, comes to a change of conceptualization of health. As a result of all this changes it has been noticed need for consideration of other aspects of health. As a outcome, indicators of disease, disability and non-biological indicators of health (as a approach to health service, quality of health protection, condition of living, life style factors and environment factors) are more and more necessary for documentation of human capacity for physical, mental and social functioning as a objective analysis of health state. To get all the information of all aspects of health which can not be get from health statistics routine data, was started with examination of population health trough interview, respectively polling out representative population sample. Aim of this studies is to get basic information about population health, in manner to supplement the picture of population states, identify health problems and health needs, to get the picture of representations of risk factors among population; to get the picture of health service utility; to find out health disparity among different countries and inside the country, among different population groups; to follow the change of health states during the time; to follow achievement in health strategy; to insure data for people which are creating health politics, in manner to coordinate theirs politics, strategy and programs. This kind of study is taking place every year in many countries and in others periodically. In our country this kind of studies were done during the year of 2000. and 2006

Elementary mercury using as cathode in process chlorine-alkali electrolyze. Mercury vapor makes in process going in work setting atmosphere. Aim of the work is to examine whether symptoms, signs and abnormal clinical and laboratory findings are in the correlation with work in the chlorine-alkali electrolyze. Examination of air pollution work setting discovers that the major factor of air pollution is mercury vapor. On periodical view at 2000, 2002 and 2004 year was examine 571 respondent, and their diagnosis was entered in report, from which was separated symptoms, signs and abnormal clinical and laboratory findings. Workers on different workplaces are exposes in different degrees. Examinees were divided in a four group according to the grade of exposure: I group day by day exposed; II group sporadically exposed; III group earlier exposed; IV group not exposed. I, II and III group are workers which work in the process chlorine-alkali electrolyze. IV group was control group and her compose administration personal. The statistical testing differences of frequency between groups according to the grade of exposure is showed there is statistical significantly difference between I and III, and II and IV groups. We are concludes that symptoms, signs and abnormal clinical and laboratory findings, statistically significantly, there is in persons which are permanently and long term worked in the chlorine-alkali electrolyze setting, from persons which are not permanently expose or nonexpose