Change in left ventricular volumes, particularly end-systolic volume index is a major representative of left ventri cular dilatation, and is a predictor of mortality after acute myocardial infarction of anterior localization. Several large-scale trials have demonstrated beneficial effectiveness of ACE inhibitors on the process of left ventricular remodeling after myo cardial infarction, not only in patients with compromised systolic function. Aim of the study was to evaluate the influence of therapy for ACE inhibitors in the early faze of anterior myocardial infarction, trough dynamics of left ventricular volume in dexes. During six months 30 patients were evaluated with echocardiography in admission, before leaving the hospital, after
three and six months after myocardial infarction. In evaluated group there was increased end-diastolic and end-systolic vo lume index, but without statistically significant value. There were no new cardiac decompensations. We concluded that ACE inhibitors given in the early stage of acute myocardial infarction anterior localization have beneficial effect on the process of left ventricular remodeling and that is recommended to bee given to this patients, after excluded contraindications

In essential hypertension, hemodynamic changes in systolic and diastolic function acompany left ventricul hypertrophy ussualy. Both of these cardiac function can be detected with echocardiography and were measured during this study. 23 patients with moderate essential hypertension were treated with cilazapril plus small doze of diuretic (hydrochlorothiazide) once daily for 120 days. On the begining we found diastolic disfunction, but after the treatment there was a significant improvement in isovolumic relaxation time, early diastolic filling pattern and normalized left ventricular early/ atrial filling ratio. Cilazapril + diuretic combination in a dose once daily controlled blood pressure satisfactory, too. Parameters of systolic function were in the normal levels and there were no significant changes between the two determinations. Thickness of the interventricular septum and posteroinferior wall did not change significantly after 16 weeks of therapy, probably because of too short time of investigation.