The pustula maligna is most often clinical form of antrax. Disease is today a relative Rarity, but its appearance (sporadic or in epidemia) always to be surprised, especially in the biology war. Antrax have a big significant and today, we analyzed clinical findings of pustula maligna and its differential diagnosis. 

Acne is a chronic inflammatory disease of the pilo sebaceous follicules. The sites involved are the seborrheic areas in sebaceous glands mainly face, upper chest, back and the shoulder areas. The usual types of acne occur puberty. Acne is rare in children and old age. Increase in the activity of sebaceous glands and occlusion of the pilosebaceous orifices are the main factors of acne pathogenesis. Androgens increase the activity of sebaceous gland in both sexes. The usual types of acne occur in some endocrine abnormality and disorders. We analyzed hormones control of the acne and its role in occurrence of acne

With this case report we want to introduce is one rare disease, which can be spontaneonsly treat, buth it has a rare return. We present a pacient with rare febrile ulcero-necrotic variant, a possible persistent variant of PLEVA. The disease has been reprted in 20-th young adult

We want to present a boy with a several different, but benign disorders. Keratosis pilaris and strophulus infantum are very frequent, esspeciallv in children. Its association is not important. Pseudoacanthosis nigricans is especially associated with obesitas, and then this disorders is benign

Pustulosis subcornealis is a chronic recurrent disorder with primarly sterile pustular lesion, initially bean-sized. The initial distribution is symmetrical and disseminated. The pustules is affected the trunk and the proximal extremities. A rare condition, affecting women. We want to present a woman with a characteristic subcorneal pustular lesions on the clinical findings and histpatology examination.

Urea is naturally present in healthy skin,but when the skin is dry, and in some skin condicions, such as eczema, psoriasis and dermatitis, the level of urea in the skin is reduced, because skin is dry and rough and irritation. Urea deserves a bigger role in our dermatotherapy and medical cosmetology-for curring skin disorders and for better care of healthy skin. Urea
helps replenish this essential skin component and help support the skin`s natural moisture levels.

In this work the authors have treated patient with a wide range of skin symptomes and a various clinical sings and
manifestations of this serious bullous skin disease. The complications such as secondary bacterial infections on eroded
areas and swallow difficulties, because mucous membrane of oral cavity was affected, have supplemantary disabled quick
and efficient therapy. Therapeutical problems were presented as weakness, exhaustion, obstruction syndrome and asthmatic
constitution of a patient. The high doses of corticosteroids could provoke a hypertension, but still, with gradually reduced
doses of corticosteroids, supported by local therapy with antibiotics and corticosteroids, we achieved rehabilitation and
healing of our patient

Vitiligo manifests with hypopigmentated and depigmentated plates on the skin and mucous membranes. Etiopathogenic mechanism of disease appearing is not completely explained, though there are theories explaning the appearance of the disease. Precipitant factors, especially psyhotic stress, are very important for the appearance of the disease. The
patients usually come because of cosmetics defects, because vitiligo areas appear mostly on uncovered parts of a body. We
are presenting a girl, with the first sings of the disease appeared when she was seven, located symetrically periorbitally and
in capilicium followed by polyosis. The beginning of the disease might be connected with a psychotic stress.