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Volume 53, Issue 4, 2025

Online ISSN: 2560-3310

ISSN: 0350-8773

Volume 53 , Issue 4, (2025)

Published: 30.06.2025.

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15.01.2014.

Science Reports

Dopamin i njegovi metaboliti u likvoru alkoholičara sa infarktom mozga

Alkoholizam je jedan od 300 do danas istraženih i utvrđenih faktora rizika za nastanak infarkta mozga. Redukovan broj neurona zbog moždanog infarkta i premorbidnog alkoholizma, uz brojne poremećaje funkcije mozga, za posledicu mora imati i oštećen metabolizam dopamina (DA), tj. metaboličkog obrta DA (3, 4 dihydroxyphenylacetic acid + homovanilic acid, DOPAC + HVA). Osnovni cilj istraživanja je dokazivanje poremećaja koncentracijskog sadržaja DA i metaboličkog obrta DA kod bolesnika sa moždanim infarktom, a premorbidnih alkoholičara, biohemijskim pregledom likvora, i to u poređenju sa nalazom u likvoru bolesnika bez akutne moždane lezije. Formirane su dve grupe hospitalno lečenih bolesnika za svrhe ovog istraživanja. Ispitivanu grupu A čini 50 bolesnika sa akutno nastalim moždanim infarktom a premorbidnih alkoholičara. Svi su mlađi od 65 godina. Kontrolnu grupu (grupa B) čini 30 bolesnika hospitalno lečenih zbog vertiginoznih smetnji, a mlađih od 65 godina. Likvor (CSF) uzet je neposredno pri prijemu na bolničko lečenje bolesnicima grupe A, a bolesnicima kontrolne grupe B u prvoj sedmici hospitalizacije i čuvan na -70°C do pregleda. Laboratorijski je utvrđen povišen sadržaj DA, kao i njegovih metabolita (DOPAC + HVA) u likvoru bolesnika sa moždanim infarktom a ranijih alkoholičara za p<0,05. Rezultati sugerišu da DA ima značajnu ulogu u nastanku ishemijskog oštećenja. Nalaz ukazuje na značajno ubrzanje metabolizma DA kod bolesnika sa moždanim infarktom a ranijih alkoholičara. Pored toga potvrđuje i značaj DA u patogenezi ishemijske smrti neurona.

M. Radomirović, Slavica Đukić Dejanović, M. Nenadović

01.01.2008.

Original scientific paper

THE APPROACH TO THE PATIENT WITH CEREBRAL-VASCULAR INSULT (STROKE) IMMEDIATE BEFORE AND AFTER NATO BOMBING

We have been analyzing a number of patients with cerebral-vascular insult in a period of 1998-2003 year, clinical picture in the time of the reception, the development of the illness, the result and the therapy access in the Neuropsychiatric Department of Health Center in Kosovska Mitrovica. It is concluded that the number of CVI is significantly higher after the NATO bombing, the development of the illness more difficult and a detailed analyses of the causes is in progress. In a period of 01. 01. 1998 until 31. 12. 2003. year, 1829 of patients have been on hospital treatment and 252 of them have been treated from CVI, in the Neuropsychiatric Department of Health in Kosovska Mitrovica. During clinical prospective, retrospective and static research in has been concluded that:in the above mentioned period the number of CVI patients have been increasing in regard to the total number of treated patients in Neuropsychiatric Department of Health Center in Kosovska Mitrovica. The percentage of CVI relapse is increasing(the highest percentage is in 1999). It has been established that besides the well known causes for the occurrence of CVI such as:hypertension, the heart disease, disorders of heart rhythm, endocrine disease(Diabetes mellitus) end also the well known factors of risk for causing of mentioned diseases(corpulence, raised value oh cholesterol in blood, smoking, insufficient physical activity, excessive consuming of alcohol etc). Relevant factor for the occurrence of CVI is the factor of stress, social and territorial isolation of the Serbian population immediate after NATO bombing on the territory of Kosovo and Metohija.

M. Radomirović

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