The importance of the examination of life quality of children having asthma is more and more emphasized in the world. Asthma is a disease which limits the persons having this disease in physical, social and mental activities. Information about life quality can only be obtained by the patients because only they have direct insight into their feelings and thoughts. Our research included 95 children having allergic asthma and 40 children having nonallergic asthma were examined. Questionnaire on life quality of children having asthma in the case of general activities PAQLQ(S), whose creator is prof. Elizabeth Juniper, was used for the examination of life quality. The results were shown by questionnaire scores (total and individual ones). Determination of the activities representing the biggest restraints in the life of examined patients gives the possibility for adequate carrying out of therapy as well as better education of the patients concerning self-control of disease.

Asthma is one of the oldest diseases although it's etiopathogenesis has been explained in more details recently. It is very commin in the general population, and especially in children's population. Lately, the rising trend of asthma is the result of the increased exposure of children to unfavourable environmental factors such as air pollutants and "new" allergens in the course of 20 to 30 years. Asthma is multifactorial disease, the interaction of many factors is responsible for its inception and deterioration. Our research included 95 children having allergic asthma and 40 children having nonallergic asthma. All examinees were interviewed by means of epidemiological questionnaire on risk factors. In that way, basic demographic data, data concerning predisposing, causal and contributing risk factors for asthma inception were gathered. The average age of children having allergic asthma was 11.18 years, and the ones having nonallergic asthma were 14.25 years. In regard to gender structure of those having asthma, asthma is more common in the case of male population (65%). The risk for allergic asthma inception is increased by air pollutants, respiratory infections, and increased level of serum IgE. The biggest relative risk is found for the increased levels of serum IgE (OP=5.839), allergy to medicines. Those are variables which increase the risk for allergic asthma inception. The above mentioned variables are predicative factors for atopy inception.

Bacterial meningitis is an infectious disease, with potentially fatal outcome, where the main event reflects inflammation of soft meninges and associated phenomena on the other structures of the central nervous system. Despite the use of powerful antibiotics and other drugs and therapeutical measurements, the number of diseased, as well as the mortality from this suerious disease, are not changed for years. The most common pathogens of bacterial meningitis in children age are H.influenzae, S.pneumoniae and N. meningitidis. Other significant causes are Streptococcus B, E.colli, L.monocytogenes, Salmonella, Pseudomonas and other Gram-negative bacteria. Our research included 120 children sufferin from bacterial meningitis. Out of the total number of treated children, the highest incidence was in age of infants (51,6%), and regarding to the gender structure, male were somewhat more frequent (54,6%). The most significant unfavorable factors for occurrence of sequalea were: younger age, the type of bacteria, bacterial concentration in cerebrospinal fluid, the time required for liquor sterilization, hypoglycorrhachia, focal neurological sings and convulsions. Complications could relate to the central nervous system or some other organic systems. Convulsions are the early complications of bacterial meningitis. Hearing impairment is often present with severe forms of bacterial meningitis with convulsions, prolonged febrile state and presence of hypoglycorrhachia. Epilepsy is rare, late sequelae, while hydrocephalus is more likely to occur in neonatal meningitis. Heavy neurological damage occures in 5% of the children.

Bacterial meningitis is an important medical problem, as because of the use of powerfull antibiotics and other
drugs, and therapeutic measures, the number of patients, as well as the mortality haven't been changed for years. Because of that the study of pathogenesis of bacterial meningitis has been one the most dynamic researsh fields in recent years. Meningitis caused by salmonella is not usual clinical manifestation of salmonella infections, but because of fulminant evolution and specific structure of cause. Path and effect of diseases, it deserves special attention. Our researches encompases 29 children who suffer from salmonella meningitis. Out of the whole number of cured children, the moust frequent was at newborn (58,6%), while the smallest number was in the group of older infant (6.9%). Concernig the sex structure of diseased, the biger number was at male (62.0%). The most important finding in liquor cerebrospinalis at patients is polymorphonuclear leucocytosis (average value of cell elements is 3744, with 82% polymorphonuclears). At the same time existed leucocytosis in peripheral blood with sigificant deviation into left. At all our patients hypoglycorachya expressed (1.45mmol/L). The value of proteinorachya was 1.71 g/L. The result of the disease was successful in 49.3%, died 24,1%, and cured with consequences 27,6%.

The aim of our work was to inquire after frequency and characteristics of repeated myocardial infarction. We questioned prospectively 123 patients, diagnosed with acute myocardial infarction, who were hospitalized in the Coronary unit
of Krusevac Health centre, during the period of 01. 02.- 31. 07. 2001. Repeated myocardial infarction was found in 16,26%
of questioned patients. Non Q acute myocardial infarction was found in 35,00% on patients with repeated myocardial infarction and 8,74% on patients with the first myocardial infarction (p<0,01). In patients with repeated myocardial infarction
more often was found heart failure (55,00% vs 20,39%, p<0,01). Repeated myocardial infarction have difficulty clinical
flow, but have not statistical significantly higher early mortality