Medical abortion (i.e. abortion induced by pharmaceutical agents) is a method of pregnancy termination administered most often in the second trimester in case of either fetal malformations or absence of fetal heart tones (missed abortion. Aim of the study was to compare effects of two regimens of drug adminstration for pregnancy termination in case of fetal anomalies registered in the second trimester of pregnancy. The investigation was performed in 52 patients of the Universitasklinik fur frauenheilkunde, Allgemaines krankenhaus (AKH), Klinische Abteilung fur Gynakologie und Geburtshilfe, Abteilung fur pranatale diagnostic und therapie and comprised two groups of patients in whom pregnancy termination was performed in the second trimester because of the presence of fetal malformations. Comparison analysis of the effect of the two regimens for pregnancy termination has been conducted in two groups of patients: Group A, who received R R R Cergem (Gemeprost) and Group B, who received a combination of Myfegine (Myfepriston) and Cyprostol (Misoprostol). Complete medical abortion occurred approximately at the same rate in both investigated groups (Group A - 10 (35.7%); Group B - 9 (37.5%). Curettage (Vacum aspiration) following the incomplete medical abortion was required in the group R R with Gemeprost in 18 (64.3%), and in the group with Myfegine /Cyprostol in 15 (62.5%) patients. A regimen of mifepristone pre-treatment followed by misoprostol applied in the Group B presented with financial benefits according to the present time prices of drugs in Austria relative to the regimen administered in the Group A, in which the cost of a single or a two-day treatment by gemeprost was significantly more expensive.

Nowadays, hysterosalpingography and laparoscopy are routine methods of exploration of the oviduct passability.The tests were made at department of infertility at the Gynecology and Obstretics Institute of Clinical Center of Serbia in the period from 01.01. untill 31.12.1998. The three hundred patients, on which hysterosalpingography (HSG) was made, and patients, on which chromolaparoscopy was made, were involved by prospectus studies. The analysis shows, that between hysterosalpingographical and laparoscopical investigation of the passability of the oviducts there exists an extremely high statistical difference in the distributions of findings of particular modalities of the passability of the oviduct. Two-way passability of the oviducts with growths of tissue has been established in a higher percentage in the patients who were examined laparoscopically, while the other alternations have been diagnosed hysterographically i a higher percentage. A statistical processing of data resulted in a significantly high statistical difference in the patients with two-way occlusion of the oviducts, whereas for other modalities no statistically significant difference has been established. The most researchers describe high perccentages of growths of tissue, from 64,0% to 72,0%, which have not been established by HSG. Growths of tissue have been confirmed by this investigation in a high percentage (70,0%). Establishing the passability of the oviducts is particularly important for further treatment of the patients.

Ahigher concentrations of microorganisms in the vagina can lead to preterm delivery. Bacterial vaginosis is a well known risk factor of preterm delivery. Aim of this study was to estimate the presence of bacterial vaginosis as a potential cause of preterm delivery relative to the patients with term delivery, as well as to define the type of present bacteria. The results of our investigation showed more frequent presence of bacterial infection of the vagina in the patients with preterm delivery. The following bacteria have been cultured in the group of patients with preterm delivery: Streptocossus agalctiae, Enterococcus, Staphylococcus sp. and Escherichia coli. In prevention of preterm delivery, we recommend a routine screening of pregnant women (such as obtaining smears to bacterial infection) as well as administration of the therapy in case of positive findings, particularly in those presenting a risk for the development of bacterial vaginosis and preterm delivery. 

Although nowadays is importance of surgery as primary method of gestational trophoblast disease treatment smaller than earlier,appliance of the surgical procedure is still valuable addition to the modern therapy of these diseases. We present a patient with mola hydatidosa where hysterectomy had been done as operative way of this disease treatment.

The genes mutate either spontaneously or under the influence of mutagenic agents (irradiation, viruses, toxins).
The occurrence of genetic syndromes in the scope of one family is pointing more to the inherited than to de novo mutation.
Aim of this study was to present two syndromes in the same family tree, occurring subsequently one by one, which carry severe mental retardation and have a poor prognosis and frequently tragic outcome. A case report was given of a patient in
whom both pregnancies were completed by birth of the newborns presenting with severe syndromes: the first one with
Down's syndrome and the second one with Prader-Willi-Labhart syndrome. The results of investigation point to the necessity of genetic investigations before pregnancy and during pregnancy as early as possible, in order to avoid giving birth to
the children with syndromes which bear severe mental retardation and having poor prognosis.

A 23-year-old primigravida in 7 weeks of pregnancy with tubal pregnancy. Clinical and ultrasound examinations indicated ectopic pregnancy; emergency laparatomy was performed. Intraoperatively, the tuabal pregnancy with a ruptured hole was revealed. Typical salpingectomy was carried out. Hystology confirmed tubal pregnancy. The postope-rative cours was normal.

Aim of the study was to determine presence and incidence of perinatal risk in the newborns presenting with the
signs of IUGR or hypotrophy <5% during a 3-year period, and in this way to point the significance of intrauterine diagnostics and special screening during the labor as to reduce the incidence of these factors. Methods: There were 18412 deliveries at the Department of Obstetrics and Gynecology in Novi Sad during the 3-year period out of which number, 560
(3.04%) newborns with IUGR or intrauterine hypertrophy <5%. Results: In the investigated population of 560 newborns
with IUGR or hypertrophy <5%, the following factors of perinatal risk have been recorded: manifest pathological cerebral
signs in 30 cases ( 5.36%), convulsive crises in 6 (1.07%), the crises of apnea and cyanosis in 10 (1.78%), intracranial hemorrhage in 17(3.03%), hyperbilirubinemia in 25 (4.46), hemolytic disease in 6 cases (1.07%), hypoglycemia in 1(0,18%),
disorders of pulmonary ventilation in 26 cases (4.64%) whereas congenital anomalies were evidented in 19 ( 3.39%)
newborn infants. Exanguination transfusion was administered in 4 (0.71%) and transfusion in 9 (1.61%) newborns with
IUGR, i.e. intrauterine hypotrophy <5. Conclusion: The results of investigation show the significant presence of perinatal
risk factors in the population of the newborns with IUGR leading to the increased morbidity in later periods of life.