Menopause is a physiological condition arising from the end of a woman's reproductive life and is defined by the gradual decline of menstrual bleeding over a period of 12 months. Hormone Replacement Therapy (HRT) is the first choise therapy in treating this condition, and prevention of early and late problems associated with hormone deficient in menopause. This study was organized on Clinics for Gynecology and obstretics in Novi sad. We were examined women knowledge about HRT, as the number of active users of HRT. Two hundred testing women were divided into two groups, arrived from city or willage regions, and they had different education level. Our results showed that number of examined persons, who were infomed about HRT, was significantly higher in city region, but number of HRT users was nearly the same for both groups. Education degree is the significant factor associated with information about HRT. High education women were better informed according to women with lower education. Irrecpective of origin and educational degree, there was statisticaly little number of women, who use HRT, despite of their aknowlegment about this way of therapy. According to our results, we conclude that, it is very important to conduct a proffesional aproach, including continual preventive action, for resolving hesitation to HRT