Helicobacter pylori infection is the largest number of infected people in the world. It is believed that 50 - 60% of world population infected, but with uneven schedule. Helicobacter pylori is the most important cause of duodenal and gastric ulcer. The prevalence of infection in different communities vary depending on geographic, racial and socioeconomic factors, and the last 10-20 years in some areas can be observed a significant reduction in the frequency of infection in both the general population and among patients with peptic ulcer. In our country, except in the territory of Vojvodina, there was no serious investigation of frequency of Helicobacter pylori infection in the general population.