Craniomandibular dysfunction are serious problem in stomatological practise from the aspect of prevention therapy and checkup. The frequency of this defect as well as its sings and symptoms were registered within randomly selected sample of examinees consisting of 70 individuals. The examinees were submitted to Fricton-Schiffman clinical function analysis wich indicated the presence of sings and symptoms of craniomandibular dysfunction. Within examined population 128 examinees had the sings and symptoms of craniomandibular dysfunction. It was determined in demographic analysis that diseased examinees were between the ages of 17 and 35 as well as that this sickness was commoner to female individuals in the ratio of 4:1. The most frequent symptoms were the following: muscles pain sensitivity to palpation (888%) lateral deformation of the lower jaw while opening the mouth (778%) and sound signals in temporomandibular joint while moving the lower jaw (77%). The highest frequency of pain sensitivity was in: m. pterigoideus lateralis m. maseter and lower insertion of m. trapesius. The most frequent sound signal was the one registered during the lateral movements of the lower jaw

Periodontal disease is a chronic inflammatory disease that is largely attributable to infections with gram-negative bacteria and is characterised by both gingival inflammation and alveolar bone resorption. Beside macrophages, the second most common cells of the gingival inflammatory infiltrat are mast cells. Mast cells are heterogenous cell population which live from six months to one year. These cells are activated by differnt immunologic and non-immunologic signals. Activated mast cells can secrete a range of substances that regulate angiogenesis, tissue remodeling and wound healing, which include both degradation and synthesis of tissue components. Apart from that, mast cells have an important role in phagocytosis, antigen processing and presentation to T-cells. It is confirmed that gingival mast cells can express matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2. This indicates that mast cells are likely to play an important role in inflammation and tissue degradation in periodontal diseases.